{"id":454,"date":"2011-01-21T20:47:57","date_gmt":"2011-01-21T20:47:57","guid":{"rendered":"https:\/\/benimyuvam.com.tr\/?p=454"},"modified":"2011-01-21T20:47:57","modified_gmt":"2011-01-21T20:47:57","slug":"hemofili","status":"publish","type":"post","link":"https:\/\/benimyuvam.com.tr\/?p=454","title":{"rendered":"Hemofili"},"content":{"rendered":"

Hemofili ço\u011funlukla genetik geçi\u015f gösteren , vücutta kan\u0131n p\u0131ht\u0131la\u015fma sisteminde rol alan ve p\u0131ht\u0131la\u015fma faktörleri olarak adland\u0131r\u0131lan proteinlerin eksikli\u011fi veya yoklu\u011fu nedeniyle ortaya ç\u0131kan ve p\u0131ht\u0131la\u015fma bozuklu\u011fu yaratan bir kan hastal\u0131\u011f\u0131d\u0131r.Bula\u015f\u0131c\u0131 de\u011fildir. Herhangi bir kanser tipi de\u011fildir. Ancak nesilden nesile geçen kal\u0131tsal bir kan hastal\u0131\u011f\u0131d\u0131r.rnrnKan\u0131n p\u0131ht\u0131la\u015fmas\u0131n\u0131n yetersiz olmas\u0131n\u0131n nedeni p\u0131ht\u0131la\u015fma fonksiyonu için mutlak gerekli olan faktör 8 adl\u0131 proteinin kanda eksik olmas\u0131d\u0131r. Yani hemofili hastas\u0131 çocuklar do\u011fumdan itibaren hayatlar\u0131 boyunca kanlar\u0131nda faktör 8 adl\u0131 proteinleri eksik olarak hayatlar\u0131n\u0131 sürdürürler.<\/p>\n

Hemofili önemsiz bir darbenin yaratt\u0131\u011f\u0131 s\u0131yr\u0131ktan vücut d\u0131\u015f\u0131na ya da bir yara olu\u015fmasa bile yumu\u015fak dokuya ve özellikle eklem içine a\u015f\u0131r\u0131 ölçüde kanamayla kendini belli eder.X kromozomunda kan\u0131n p\u0131ht\u0131la\u015fma sürecinin normal biçimde geli\u015fmesi için zorunlu bir gen bulundu\u011fu san\u0131lmaktad\u0131r. Erke\u011fin X kromozomunda p\u0131ht\u0131la\u015fmadan sorumlu sa\u011flam bir gen yerine, bozuk bir gen varsa hemofiliye özgü p\u0131ht\u0131la\u015fma bozukluklar\u0131 ortaya ç\u0131kar.<\/p>\n

Hemofili hastalar\u0131nda meydana gelen kanamalar, olmayan faktörün yerine konmas\u0131 ile durdurulabilir. Bunun için iki çe\u015fit faktör üretilmektedir:<\/p>\n

Plazma kaynakl\u0131 faktörler:<\/strong> insanlardan toplanan kanlar bir havuzda toplan\u0131r, faktörler ayr\u0131\u015ft\u0131r\u0131l\u0131r, viral inaktivasyondan (kan içinde olabilecek viruslar temizlenir) geçer ve paketlenir. Bu ürünler her ne kadar viral inaktivasyon yöntemlerinden geçmekteyse de insandan insana bula\u015fabilecek bir tak\u0131m viruslar\u0131 ta\u015f\u0131ma riski vard\u0131r.<\/p>\n

Rekombinat DNA teknolojisi ile elde edilen faktörler: <\/strong>insülinin üretimi gibidir. Bir vektör kullan\u0131larak faktör elde edilmektedir. \u0130çinde insana ait herhangi bir madde olmad\u0131\u011f\u0131 için hastal\u0131k bula\u015ft\u0131rma riski yoktur. Ürünümüz bu yolla elde edilir.<\/p>\n

Ülkemizde henüz rekombinant faktör ürünü yoktur. Halen plazma kaynakl\u0131 faktörler kullan\u0131lmaktad\u0131r.<\/p>\n

Emel \u0130lhan
\n<\/strong>Okul Öncesi E\u011fitmeni<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Hemofili ço\u011funlukla genetik geçi\u015f gösteren , vücutta kan\u0131n p\u0131ht\u0131la\u015fma sisteminde rol alan ve p\u0131ht\u0131la\u015fma faktörleri olarak adland\u0131r\u0131lan proteinlerin eksikli\u011fi veya […]<\/p>\n","protected":false},"author":2,"featured_media":455,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[417,365,544,525,509,526],"tags":[],"class_list":["post-454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cocuk-hastaliklari-cocuk","category-cocuk-sagligi","category-cocukta-okul-sorunlari-problemleri","category-engel-turleri","category-engelli-yasam","category-genetik-hastaliklar"],"yoast_head":"\r\nHemofili - 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